Progression of ECG in hydroxychloroquine overdose

Arushi Thaper; Steven J Ross; Zubin Agarwal; Michael Langston; William M Miles; Adam Austin

doi:10.1016/j.jelectrocard.2023.01.002

Progression of ECG in hydroxychloroquine overdose

J Electrocardiol. 2023 Mar-Apr:77:68-71. doi: 10.1016/j.jelectrocard.2023.01.002. Epub 2023 Jan 7.

Authors

Arushi Thaper¹, Steven J Ross², Zubin Agarwal², Michael Langston³, William M Miles², Adam Austin⁴

Affiliations

¹ Department of Medicine, University of Florida, Gainesville, FL, United States of America.
² Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States of America.
³ Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States of America.
⁴ Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States of America. Electronic address: [email protected].

PMID: 36652870
DOI: 10.1016/j.jelectrocard.2023.01.002

Abstract

Hydroxychloroquine overdose is associated with myocardial toxicity and conduction disorders. We report a case of hydroxychloroquine overdose that demonstrated a rapid progressive intraventricular conduction delay and QT prolongation resulting in significant bradycardia and shock despite aggressive treatment. We describe the rare capture of abrupt abnormalities of this overdose in sequential electrocardiograms in the immediate hours post-ingestion.

Keywords: Cardiac toxicity; Hydroxychloroquine; Overdose; QRS prolongation.

Publication types

Case Reports

MeSH terms

Bradycardia / chemically induced
Bradycardia / diagnosis
Drug Overdose* / diagnosis
Drug Overdose* / drug therapy
Electrocardiography
Humans
Hydroxychloroquine / therapeutic use
Long QT Syndrome* / drug therapy

Substances

Hydroxychloroquine