Abstract
Some derivatives of N-(5-pyrimidinyl)benzenesulfonamide, variously substituted at the benzene and pyrimidine ring, and variously methylated at ring and/or sulfonamidic nitrogens, were re-prepared. The activity of these compounds against lymphocytic leukemia P388 was evaluated and proved to be negligible or completely absent.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Chemical Phenomena
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Chemistry
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Leukemia P388 / drug therapy
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Mice
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Mice, Inbred Strains
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Sulfonamides / chemical synthesis*
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Sulfonamides / pharmacology
Substances
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Antineoplastic Agents
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Pyrimidines
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Sulfonamides