From Bench to Bedside in Rheumatoid Arthritis from the "2022 GISEA International Symposium"

Antonio Vitale; Stefano Alivernini; Roberto Caporali; Giulia Cassone; Dario Bruno; Luca Cantarini; Giuseppe Lopalco; Maurizio Rossini; Fabiola Atzeni; Ennio Giulio Favalli; Fabrizio Conti; Elisa Gremese; Florenzo Iannone; Gian Franco Ferraccioli; Giovanni Lapadula; Marco Sebastiani

doi:10.3390/jcm12020527

From Bench to Bedside in Rheumatoid Arthritis from the "2022 GISEA International Symposium"

J Clin Med. 2023 Jan 9;12(2):527. doi: 10.3390/jcm12020527.

Authors

Antonio Vitale¹, Stefano Alivernini^{2

3}, Roberto Caporali^{4

5}, Giulia Cassone⁶, Dario Bruno², Luca Cantarini¹, Giuseppe Lopalco⁷, Maurizio Rossini⁸, Fabiola Atzeni⁹, Ennio Giulio Favalli^{4

5}, Fabrizio Conti¹⁰, Elisa Gremese^{2

11}, Florenzo Iannone⁷, Gian Franco Ferraccioli¹², Giovanni Lapadula⁷, Marco Sebastiani⁶

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, 53100 Siena, SI, Italy.
² Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, RM, Italy.
³ Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, RM, Italy.
⁴ Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milano, MI, Italy.
⁵ Department of Clinical Sciences and Community Health, Research Center for Pediatric and Adult Rheumatic Diseases (RECAP.RD), University of Milan, 20122 Milano, MI, Italy.
⁶ Rheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of Modena and Reggio Emilia, 41121 Modena, MO, Italy.
⁷ Rheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, 70121 Bari, BA, Italy.
⁸ Rheumatology Unit, University of Verona, Policlinico G.B. Rossi, Piazzale A. Scuro, 37134 Verona, VR, Italy.
⁹ Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, 98122 Messina, ME, Italy.
¹⁰ Lupus Clinic, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, 00185 Roma, RM, Italy.
¹¹ Division of Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 20123 Milano, MI, Italy.
¹² Scuola di Medicina, Università Cattolica del Sacro Cuore, 20123 Milano, MI, Italy.

Abstract

While precision medicine is still a challenge in rheumatic disease, in recent years many advances have been made regarding pathogenesis, the treatment of inflammatory arthropathies, and their interaction. New insight into the role of inflammasome and synovial tissue macrophage subsets as predictors of drug response give hope for future tailored therapeutic strategies and a personalized medicine approach in inflammatory arthropathies. Here, we discuss the main pathogenetic mechanisms and therapeutic approaches towards precision medicine in rheumatoid arthritis from the 2022 International GISEA/OEG Symposium.

Keywords: inflammasome; inflammatory arthropathies; pathogenesis; synovial tissue macrophage; therapy.

Publication types

Review

Grants and funding

This research received no external funding.