Candida khanbhai sp. nov., a new clinically relevant yeast within the Candida haemulonii species complex

Med Mycol. 2023 Feb 3;61(2):myad009. doi: 10.1093/mmy/myad009.

Abstract

Invasive fungal infections caused by non-albicans Candida species are increasingly reported. Recent advances in diagnostic and molecular tools enabled better identification and detection of emerging pathogenic yeasts. The Candida haemulonii species complex accommodates several rare and recently described pathogenic species, C. duobushaemulonii, C. pseudohaemulonii, C. vulturna, and the most notorious example is the outbreak-causing multi-drug resistant member C. auris. Here, we describe a new clinically relevant yeast isolated from geographically distinct regions, representing the proposed novel species C. khanbhai, a member of the C. haemulonii species complex. Moreover, several members of the C. haemulonii species complex were observed to be invalidly described, including the clinically relevant species C. auris and C. vulturna. Hence, the opportunity was taken to correct this here, formally validating the names of C. auris, C. chanthaburiensis, C. konsanensis, C. metrosideri, C. ohialehuae, and C. vulturna.

Keywords: Candida auris; Candida haemulonii species complex; Candida vulturna; antifungal resistant; emerging pathogen; misidentification.

Plain language summary

Although C. albicans remains the major pathogenic yeast, other previously rare or even novel species are on the rise in the clinic. The most notorious example is the rapid global emergence of multidrug-resistant C. auris. Here we describe its novel sibling species C. khanbhai.

MeSH terms

  • Animals
  • Antifungal Agents
  • Candida / genetics
  • Candidiasis* / microbiology
  • Candidiasis* / veterinary
  • Invasive Fungal Infections* / veterinary
  • Saccharomyces cerevisiae

Substances

  • Antifungal Agents

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