The minimum weight and age of kidney donors: en bloc kidney transplantation from preterm neonatal donors weighing less than 1.2 kg to adult recipients

Am J Transplant. 2023 Aug;23(8):1264-1267. doi: 10.1016/j.ajt.2022.11.023. Epub 2023 Jan 11.

Abstract

En bloc kidney transplantation (EBKT) to adults from preterm neonates following donation after circulatory death has not been described in the literature. We report 2 successful cases of EBKT from preterm neonatal donation after circulatory death donors weighing <1.2 kg to adult recipients. The first case was a preterm female infant born at 29 weeks' gestational age, weighing 1.07 kg. The recipient was a 34-year-old woman weighing 75 kg. At the 9-month follow-up, the patient demonstrated excellent graft function with a creatinine concentration of 1.48 mg/dL. The second donor was a preterm female infant born at 29 weeks and 5 days' gestation, weighing 1.17 kg. The recipient was a 25-year-old woman weighing 46 kg. By 5 months post surgery, the serum creatinine level had gradually decreased to 1.47 mg/dL. In our experience, EBKT from preterm neonates <30 weeks' gestation and weighing <1.2 kg has demonstrated acceptable short- to medium-term results.

Keywords: clinical research/practice; donors and donation: donor evaluation; donors and donation: extended criteria; kidney transplantation/nephrology.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Creatinine
  • Female
  • Graft Survival
  • Humans
  • Infant
  • Infant, Newborn
  • Kidney Transplantation*
  • Retrospective Studies
  • Tissue Donors

Substances

  • Creatinine