Two New C19 -Diterpenoid Alkaloids from Delphinium shawurense

Chem Biodivers. 2023 Mar;20(3):e202200936. doi: 10.1002/cbdv.202200936. Epub 2023 Feb 9.

Abstract

Shawurenine C (1a) and D (1b), a new pair of regioisomeric C19 -diterpenoid alkaloids, and five known C19 -diterpenoid alkaloids (2-6) were isolated from the aerial part of Delphinium shawurense W. T. Wang. The chemical structures of new compounds were established based on spectroscopic analyses: HR-ESI-MS, and 1D, 2D NMR spectroscopic data. The anti-inflammatory and cytotoxic activities of these diterpenoid alkaloids were also evaluated.

Keywords: C19-diterpenoid alkaloids; Delphinium sharwurense; anti-inflammatory; cytotoxic activity; shawurenine.

MeSH terms

  • Alkaloids* / chemistry
  • Alkaloids* / pharmacology
  • Delphinium* / chemistry
  • Diterpenes* / chemistry
  • Diterpenes* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure

Substances

  • Alkaloids
  • Diterpenes