Application and trend of bioluminescence imaging in metabolic syndrome research

Front Chem. 2023 Jan 9:10:1113546. doi: 10.3389/fchem.2022.1113546. eCollection 2022.

Abstract

Bioluminescence imaging is a non-invasive technology used to visualize physiological processes in animals and is useful for studying the dynamics of metabolic syndrome. Metabolic syndrome is a broad spectrum of diseases which are rapidly increasing in prevalence, and is closely associated with obesity, type 2 diabetes, nonalcoholic fatty liver disease, and circadian rhythm disorder. To better serve metabolic syndrome research, researchers have established a variety of animal models expressing luciferase, while also committing to finding more suitable luciferase promoters and developing more efficient luciferase-luciferin systems. In this review, we systematically summarize the applications of different models for bioluminescence imaging in the study of metabolic syndrome.

Keywords: adipose inflammation; bioluminescence imaging; circadian rhythm disorders; metabolic syndrome; model; non-alcoholic fatty liver; obesity; type 2 diabetes.

Publication types

  • Review

Grants and funding

This work was supported by the National Science Foundation of China (82070869).