The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives

Wenqing Zhang; Qingyuan Wu; Shilei Hao; Shengli Chen

doi:10.3389/fnins.2022.1117999

The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives

Front Neurosci. 2023 Jan 12:16:1117999. doi: 10.3389/fnins.2022.1117999. eCollection 2022.

Authors

Wenqing Zhang^{1

2}, Qingyuan Wu², Shilei Hao³, Shengli Chen²

Affiliations

¹ School of Medicine, Chongqing University, Chongqing, China.
² Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China.
³ Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.

Abstract

Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly because its mechanisms are still unclear. Inflammation is one of the main types of secondary injury after ICH and catalyzes the adverse consequences of ICH. A large number of immune cells are involved in neuroinflammation, such as microglia, astrocytes, oligodendrocytes, lymphocytes, macrophages, and neutrophils. Nevertheless, the characteristics and crosstalk of immune cells have not been fully elucidated. In this review, we endeavor to delve into the respective characteristics of immune cells and their interactions in neuroimmune inflammation, and further elucidate favorable immunotherapeutic approaches regarding ICH, and finally present an outlook.

Keywords: crosstalk; hallmark; immune cells; intracerebral hemorrhage; neuroinflammation.

Publication types

Review

Grants and funding

This work was sponsored by the Fundamental Research Funds for the Central Universities (2020CDJYGSX006) and National Natural Science Foundation of China (11972099).