SMARCB1(INI-1)-deficient sinonasal carcinoma is a rare, poorly differentiated neoplasm with a poor prognosis. Though historically most were identified as sinonasal undifferentiated carcinoma, we now understand it to be a distinct entity. There is currently a general consensus supporting multimodal therapy, though the optimal sequence of surgery, chemotherapy, and radiation has yet to be defined.
Keywords: EZH2; INI-1; SMARCB1; SMARCB1(INI-1)-deficient; SNUC; SWI/SNF; SWItch/Sucrose non-fermentable; sinonasal carcinoma; sinonasal undifferentiated carcinoma.
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