Two novel variants that disrupt the RHCE start codon with varying effect on RhCE antigen expression

Transfusion. 2023 Apr;63(4):E12-E14. doi: 10.1111/trf.17256. Epub 2023 Feb 1.

Authors

Sunitha Vege¹, Aline Floch^{2

3}, Anna Burgos¹, Toufik Tahiri¹, Julie Kirkegaard⁴, Megan Dupont⁴, Gorka Ochoa-Garay¹, Christine Lomas-Francis¹, Connie M Westhoff¹

Affiliations

¹ Immunohematology and Genomics Laboratory, New York Blood Center Enterprises, Long Island City, New York, USA.
² Tablissement francais du sang Ile-de-France, Creteil, France.
³ Univ Paris Est Creteil, INSERM U955 Equipe Transfusion et maladies du globule rouge, IMRB, Creteil, France.
⁴ Immunohematology reference laboratory, Community Blood Center of Kansas City, Kansas, Missouri, USA.

PMID: 36722377
DOI: 10.1111/trf.17256

No abstract available

Keywords: RhCE typing discrepancy; start codon variant; variant RHCE alleles.

MeSH terms

Alleles
Codon, Initiator / genetics
Gene Frequency
Genotype
Humans
Rh-Hr Blood-Group System* / genetics

Substances

Codon, Initiator
Rh-Hr Blood-Group System
RHCE protein, human