Undetectable JC virus CSF PCR in patients with JC virus-induced progressive multifocal leukoencephalopathy

Chia-Yu Chiu; Eva Amenta; Violeta Chavez; Yuriko Fukuta; Rodrigo Hasbun

doi:10.1007/s13365-023-01113-7

Undetectable JC virus CSF PCR in patients with JC virus-induced progressive multifocal leukoencephalopathy

J Neurovirol. 2023 Feb;29(1):94-99. doi: 10.1007/s13365-023-01113-7. Epub 2023 Feb 1.

Authors

Chia-Yu Chiu¹, Eva Amenta², Violeta Chavez³, Yuriko Fukuta², Rodrigo Hasbun⁴

Affiliations

¹ Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin St, STE MSB 2112, Houston, TX, USA. [email protected].
² Section of Infectious Diseases, Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
³ Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
⁴ Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin St, STE MSB 2112, Houston, TX, USA.

PMID: 36723823
DOI: 10.1007/s13365-023-01113-7

Abstract

The diagnosis of progressive multifocal leukoencephalopathy (PML) is based on a combination of clinical, radiographic, and laboratory findings. However, negative JC polyomavirus (JCPyV) PCR in CSF does not always rule out JCPyV-related PML. In this narrative review, we sought to examine the characteristic of biopsy-proven PML in patients with undetectable JCPyV CSF PCR and provide alternative approaches in this scenario.

Keywords: BK virus; Brainstem; Cerebellum; JC virus; Posterior fossa; Progressive multifocal leukoencephalopathy.

Publication types

Review

MeSH terms

Humans
JC Virus* / genetics
Leukoencephalopathy, Progressive Multifocal*
Polymerase Chain Reaction