Preservation of human heart valves for replacement in children with heart valve disease: past, present and future

Cell Tissue Bank. 2024 Mar;25(1):67-85. doi: 10.1007/s10561-023-10076-2. Epub 2023 Feb 1.

Abstract

Valvular heart disease affects 30% of the new-borns with congenital heart disease. Valve replacement of semilunar valves by mechanical, bioprosthetic or donor allograft valves is the main treatment approach. However, none of the replacements provides a viable valve that can grow and/or adapt with the growth of the child leading to re-operation throughout life. In this study, we review the impact of donor valve preservation on moving towards a more viable valve alternative for valve replacements in children or young adults.

Keywords: Allograft heart valve; Congenital heart disease; Preservation; Tissue biobanking; Valve replacement.

Publication types

  • Review

MeSH terms

  • Aortic Valve / surgery
  • Child
  • Heart Valve Diseases* / surgery
  • Heart Valve Prosthesis*
  • Humans
  • Preservation, Biological
  • Young Adult