Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines

Ellen Fraint; Hisham Abdel-Azim; Neel S Bhatt; Larisa Broglie; Asma Chattha; Mira Kohorst; Yiouli P Ktena; Michelle A Lee; Susie Long; Muna Qayed; Akshay Sharma; Heather Stefanski; Anant Vatsayan; Lisa Wray; Mehdi Hamadani; Paul A Carpenter

doi:10.1016/j.jtct.2023.02.003

Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines

Transplant Cell Ther. 2023 May;29(5):293-301. doi: 10.1016/j.jtct.2023.02.003. Epub 2023 Feb 10.

Authors

Ellen Fraint¹, Hisham Abdel-Azim², Neel S Bhatt³, Larisa Broglie⁴, Asma Chattha⁵, Mira Kohorst⁶, Yiouli P Ktena⁷, Michelle A Lee⁸, Susie Long⁹, Muna Qayed¹⁰, Akshay Sharma¹¹, Heather Stefanski¹², Anant Vatsayan¹³, Lisa Wray¹⁴, Mehdi Hamadani¹⁵, Paul A Carpenter³

Affiliations

¹ Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore, Bronx, New York. Electronic address: [email protected].
² Loma Linda University School of Medicine, Cancer Center, Children's Hospital and Medical Center, Loma Linda, California.
³ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.
⁴ Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation, Milwaukee, Wisconsin.
⁵ Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
⁶ Department of Pediatric and Adolescent Medicine, Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, Minnesota.
⁷ Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
⁸ Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore, Bronx, New York.
⁹ University of Minnesota Masonic Children's Hospital, MHealth Fairview Acute Care Pharmacy Services, Minneapolis, Minnesota.
¹⁰ Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
¹¹ Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, Tennessee.
¹² National Marrow Donor Program, Minneapolis, Minnesota.
¹³ Children's National Medical Center, Washington, District of Columbia.
¹⁴ Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
¹⁵ BMT & Cellular Therapy Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

PMID: 36775202
DOI: 10.1016/j.jtct.2023.02.003

Abstract

Evaluation of a candidate for hematopoietic cell transplantation (HCT) is a complex process with substantial intercenter variability. Although literature providing guidance for evaluating the eligibility of adults is well established, similar guidance for children is lacking. To address gaps between adult recommendations and the specific needs of children, we convened a panel of pediatric HCT experts from a wide geographic range of American Society of Transplantation and Cellular Therapy (ASTCT) member institutions to offer recommendations for pediatric-focused pre-HCT evaluation. In this report from the ASTCT Committee on Practice Guidelines, we present a practical framework for evaluating children with malignancies who are candidates for HCT. We also highlight key differences from adults and emphasize areas of unmet need that require additional research to delineate best practices.

Keywords: Pediatric hematopoietic cell transplantation; Pediatric malignancy; Pretransplantation evaluation; Transplantation candidate.

Publication types

Practice Guideline

MeSH terms

Adult
Bone Marrow
Child
Hematopoietic Stem Cell Transplantation*
Humans
Neoplasms* / therapy
Research Report
Transplantation, Homologous
United States