Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13.

Abstract

Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Apolipoprotein C-III
  • Inflammasomes*
  • NLR Family, Pyrin Domain-Containing 3 Protein*

Substances

  • Apolipoprotein C-III
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein