X marks the shot against malaria

Immunity. 2023 Feb 14;56(2):234-236. doi: 10.1016/j.immuni.2023.01.018.

Abstract

The development of a transmission-blocking vaccine (TBV) against malaria is hampered by poor understanding of functional antibody responses. In this issue of Immunity, Fabra-Garcia et al., Ivanochko et al., and Tang et al. isolate human monoclonal antibodies against the two most promising TBV candidates, Pfs48/45 and Pfs230, and map the epitopes responsible for potent transmission-reducing activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Humans
  • Malaria Vaccines*
  • Malaria* / prevention & control
  • Malaria, Falciparum* / prevention & control
  • Plasmodium falciparum
  • Protozoan Proteins

Substances

  • Protozoan Proteins
  • Malaria Vaccines
  • Antibodies, Protozoan
  • Antigens, Protozoan