Temporary Vascular Occlusion with Retrievable Microvascular Plugs to Protect Normal Liver during Yttrium-90 Radioembolization

Federico Pedersoli; Franz Edward Boas; John J Park

doi:10.1016/j.jvir.2023.02.012

Temporary Vascular Occlusion with Retrievable Microvascular Plugs to Protect Normal Liver during Yttrium-90 Radioembolization

J Vasc Interv Radiol. 2023 Jun;34(6):978-982. doi: 10.1016/j.jvir.2023.02.012. Epub 2023 Feb 15.

Authors

Federico Pedersoli¹, Franz Edward Boas¹, John J Park²

Affiliations

¹ Division of Interventional Radiology, Department of Radiology, City of Hope Comprehensive Cancer Center, Duarte, California.
² Division of Interventional Radiology, Department of Radiology, City of Hope Comprehensive Cancer Center, Duarte, California. Electronic address: [email protected].

PMID: 36796477
DOI: 10.1016/j.jvir.2023.02.012

Abstract

This case series describes a technique to protect nondiseased liver parenchyma during transarterial radioembolization (TARE) using microvascular plugs to occlude nontarget vessels temporarily and protect normal liver. This technique, defined as temporary vascular occlusion, was performed in 6 patients, with complete vessel occlusion obtained in 5 of the 6 patients and partial occlusion with flow reduction in 1 of the 6 patients. A statistically significant (P = .001) dose decrease of 5.7 ± 3.1 times was measured using postadministration yttrium-90 positron emission tomography/computed tomography in the protected zone compared with that in the treated zone.

MeSH terms

Carcinoma, Hepatocellular* / therapy
Embolization, Therapeutic* / adverse effects
Embolization, Therapeutic* / methods
Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / drug therapy
Liver Neoplasms* / radiotherapy
Retrospective Studies
Treatment Outcome
Yttrium Radioisotopes / adverse effects

Substances

Yttrium-90
Yttrium Radioisotopes