Abstract
Intravenous cocaine use is a major problem in methadone maintenance programs. In this pilot study of 16 cocaine-abusing methadone maintenance patients, 8 received desipramine and 8 received no medication other than methadone. During an 8-week open trial the desipramine patients reported significantly less cocaine craving and had less cocaine use than the other patients.
MeSH terms
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Adult
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Antisocial Personality Disorder / psychology
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Black or African American
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Cocaine*
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Desipramine / therapeutic use*
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Female
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Humans
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Male
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Methadone / therapeutic use*
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Opioid-Related Disorders / complications
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Opioid-Related Disorders / rehabilitation*
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Substance-Related Disorders / complications
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Substance-Related Disorders / drug therapy*
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Substance-Related Disorders / rehabilitation
Substances
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Cocaine
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Desipramine
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Methadone