Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

Shao-Bin Wang; Yosuke Nagasaka; Dionne Argyle; Ayami Nagasaka; Praveen Yerramothu; Bradley D Gelfand; Jayakrishna Ambati

doi:10.1038/s41392-022-01277-4

Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

Signal Transduct Target Ther. 2023 Feb 20;8(1):72. doi: 10.1038/s41392-022-01277-4.

Authors

Shao-Bin Wang^#^{1

2}, Yosuke Nagasaka^#^{3

4}, Dionne Argyle^{3

4}, Ayami Nagasaka^{3

4}, Praveen Yerramothu^{3

4}, Bradley D Gelfand^{3

4

5}, Jayakrishna Ambati^{6

7

8

9}

Affiliations

¹ Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].
² Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].
³ Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
⁴ Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
⁵ Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA.
⁶ Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].
⁷ Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].
⁸ Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].
⁹ Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism
Choroidal Neovascularization* / drug therapy
Choroidal Neovascularization* / genetics
Humans
RNA, Messenger / genetics
Vascular Endothelial Growth Factor A* / genetics
Vascular Endothelial Growth Factors

Substances

RNA, Messenger
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
FTO protein, human
Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Publication types

MeSH terms

Substances

Grants and funding