Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population

Taeko K Naruse; Makiko Konishi-Takemura; Risa Yanagida; Gaurav Sharma; Madhu Vajpayee; Hiroshi Terunuma; Narinder K Mehra; Gurvinder Kaur; Akinori Kimura

doi:10.1111/iji.12617

Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population

Int J Immunogenet. 2023 Apr;50(2):48-52. doi: 10.1111/iji.12617. Epub 2023 Feb 17.

Authors

Affiliations

¹ Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
² Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
³ Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.
⁴ Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
⁵ Biotherapy Institute of Japan, Tokyo, Japan.
⁶ Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 36807537
DOI: 10.1111/iji.12617

Abstract

One of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV-1 infection in the Japanese and Indian populations, implying that KIR3DL1*007-positive NK cells might eliminate HIV-infected cells less effectively than NK cells bearing the other KIR3DL1 alleles or KIR3DS1 alleles.

Keywords: HIV-1; KIR3DL1; NK receptors.

MeSH terms

Alleles
Disease Progression
East Asian People*
HIV / genetics
HIV Infections* / genetics
HLA-B Antigens / genetics
Humans
Receptors, KIR / genetics
Receptors, KIR3DS1 / genetics

Substances

Receptors, KIR3DS1
Receptors, KIR
HLA-B Antigens

Abstract

MeSH terms

Substances

Grants and funding