We tested coatis (Nasua nasua) living in an urban park near a densely populated area of Brazil and found natural SARS-CoV-2 Zeta variant infections by using quantitative reverse transcription PCR, genomic sequencing, and serologic surveillance. We recommend a One Health strategy to improve surveillance of and response to COVID-19.
Keywords: Brazil; COVID-19; SARS; SARS-CoV-2; coatis; coronavirus; coronavirus disease; natural infections; respiratory infections; severe acute respiratory syndrome coronavirus 2; spillback; urban parks; viruses; wildlife; zoonoses.