Development of a Polyherbal Topical Gel for the Treatment of Acne

Benedict Jose Chellathurai; Ramyadevi Anburose; Mohammad H Alyami; Mohan Sellappan; Mohammad F Bayan; Balakumar Chandrasekaran; Kumarappan Chidambaram; Mohamed Rahamathulla

doi:10.3390/gels9020163

Development of a Polyherbal Topical Gel for the Treatment of Acne

Gels. 2023 Feb 17;9(2):163. doi: 10.3390/gels9020163.

Authors

Benedict Jose Chellathurai¹, Ramyadevi Anburose¹, Mohammad H Alyami², Mohan Sellappan¹, Mohammad F Bayan³, Balakumar Chandrasekaran³, Kumarappan Chidambaram⁴, Mohamed Rahamathulla⁵

Affiliations

¹ Department of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore 641 032, Tamil Nadu, India.
² Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.
³ Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan.
⁴ Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
⁵ Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62421, Saudi Arabia.

Abstract

The present work aimed to formulate and evaluate a polyherbal gel using Aloe barbadensis and extract of Vigna radiata for the treatment of acne, a disorder of the skin in which hair follicles and sebaceous glands are blocked, causing inflammation and redness of the skin. Aloe barbadensis pulp was collected and mixed with the extract of Vigna radiata and formulated into a gel using Carbopol 940, triethanolamine, and propylene glycol as the gelling agent, viscosity modifier, and pH modifier, respectively. The gel was evaluated for its antimicrobial properties against Staphylococcus aureus, Escherichia coli, and Candida albicans. Antimicrobial agents, such as gentamycin and fluconazole, were used as the standards. The developed formulation showed promising zone of inhibition. The gel was further evaluated for its physicochemical properties. The formulation showed a promising effect on acne together with the additive effect of Aloe barbadensis on skin.

Keywords: Aloe barbadensis; Carbopol 940; Vigna radiata; acne; polyherbal gel.

Grants and funding

The authors are thankful to the Deanship of Scientific Research at Najran University for funding this work, under the General Research Funding program grant code (NU/RG/MRC/12/20). The authors (B.J.C., R.A. and M.S.) are grateful to the management of Karpagam Institutions for providing the facility to carry out the research work. The authors (M.F.B. and B.C.) gratefully acknowledge the management of Philadelphia University in Jordan for the research support (No. 511/34/100 PU).