Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH-HCC Guidelines)

Kiyoshi Hasegawa; Nobuyuki Takemura; Tatsuya Yamashita; Takeyuki Watadani; Masaki Kaibori; Shoji Kubo; Mitsuo Shimada; Hiroaki Nagano; Etsuro Hatano; Hiroshi Aikata; Hiroko Iijima; Kazuomi Ueshima; Kazuyoshi Ohkawa; Takuya Genda; Kaoru Tsuchiya; Takuji Torimura; Masafumi Ikeda; Junji Furuse; Masaaki Akahane; Satoshi Kobayashi; Hideyuki Sakurai; Atsuya Takeda; Takamichi Murakami; Utaroh Motosugi; Yutaka Matsuyama; Masatoshi Kudo; Ryosuke Tateishi; committee for Revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma, Tokyo, Japan

doi:10.1111/hepr.13892

Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH-HCC Guidelines)

Hepatol Res. 2023 May;53(5):383-390. doi: 10.1111/hepr.13892. Epub 2023 Mar 10.

Authors

Kiyoshi Hasegawa¹, Nobuyuki Takemura², Tatsuya Yamashita³, Takeyuki Watadani⁴, Masaki Kaibori⁵, Shoji Kubo⁶, Mitsuo Shimada⁷, Hiroaki Nagano⁸, Etsuro Hatano⁹, Hiroshi Aikata¹⁰, Hiroko Iijima¹¹, Kazuomi Ueshima¹², Kazuyoshi Ohkawa¹³, Takuya Genda¹⁴, Kaoru Tsuchiya¹⁵, Takuji Torimura¹⁶, Masafumi Ikeda¹⁷, Junji Furuse¹⁸, Masaaki Akahane¹⁹, Satoshi Kobayashi²⁰, Hideyuki Sakurai²¹, Atsuya Takeda²², Takamichi Murakami²³, Utaroh Motosugi²⁴, Yutaka Matsuyama²⁵, Masatoshi Kudo¹², Ryosuke Tateishi²⁶; committee for Revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma, Tokyo, Japan

Affiliations

¹ Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
² Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
³ Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.
⁴ Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁵ Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Japan.
⁶ Department of Hepato-Biliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
⁷ Department of Digestive and Transplant Surgery, Tokushima University Hospital, Tokushima, Japan.
⁸ Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
⁹ Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
¹⁰ Department of Medicine and Molecular Science, Hiroshima University Hospital, Hiroshima, Japan.
¹¹ Division of Gastroenterology and Hepatobiliary, Department of Internal Medicine, Hyogo Medical University, Nishinomiya, Japan.
¹² Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Higashi-osaka, Japan.
¹³ Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.
¹⁴ Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Izunokuni, Japan.
¹⁵ Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Japan.
¹⁶ Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
¹⁷ Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
¹⁸ Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.
¹⁹ Department of Radiology, School of Medicine, International University of Health and Welfare, Otawara, Japan.
²⁰ Department of Quantum Medical Technology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
²¹ Department of Radiation Oncology, University of Tsukuba Faculty of Medicine, Tsukuba, Japan.
²² Radiation Oncology Center, Ofuna Chuo Hospital, Kamakura, Japan.
²³ Department of Radiology, Kobe University Graduate School of Medicine, Hyogo, Japan.
²⁴ Department of Diagnostic Radiology, Kofu Kyoritsu Hospital, Kofu, Japan.
²⁵ Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
²⁶ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

PMID: 36826411
DOI: 10.1111/hepr.13892

Abstract

The fifth version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence-based medicine and partly to the Grading of Recommendations Assessment, Development and Evaluation system, which was published in October 2021 in Japanese. In addition to surveillance-diagnostic and treatment algorithms, a new algorithm for systemic therapy has been created, as multiple drugs for hepatocellular carcinoma can be currently selected. Here, new or revised algorithms and evidence on which the recommendations are based are described.

Keywords: algorithm for surveillance and diagnosis; algorithm for systemic therapy; algorithm for treatment; clinical practice guidelines; hepatocellular carcinoma.

Grants and funding

None.