Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE-BD group

Paola Lavin; Soham Rej; Andrew T Olagunju; Antonio L Teixeira; Annemieke Dols; Martin Alda; Osvaldo P Almeida; Kursat Altinbas; Vicent Balanzá-Martínez; Izabela G Barbosa; Hilary P Blumberg; Farren Briggs; Cynthia Calkin; Kristin Cassidy; Brent P Forester; Orestes V Forlenza; Tomas Hajek; Barthomeus C M Haarman; Esther Jimenez; Beny Lafer; Benoit Mulsant; Stephen O Oluwaniyi; Regan Patrick; Joaquim Radua; Sigfried Schouws; Harmehr Sekhon; Christian Simhandl; Jair C Soares; Shang-Ying Tsai; Eduard Vieta; Luca M Villa; Martha Sajatovic; Lisa T Eyler

doi:10.1111/bdi.13312

Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE-BD group

Bipolar Disord. 2023 Nov;25(7):554-563. doi: 10.1111/bdi.13312. Epub 2023 Mar 10.

Authors

Paola Lavin¹, Soham Rej¹, Andrew T Olagunju², Antonio L Teixeira³, Annemieke Dols^{4

5}, Martin Alda⁶, Osvaldo P Almeida⁷, Kursat Altinbas⁸, Vicent Balanzá-Martínez⁹, Izabela G Barbosa¹⁰, Hilary P Blumberg¹¹, Farren Briggs¹², Cynthia Calkin⁶, Kristin Cassidy¹², Brent P Forester¹³, Orestes V Forlenza¹⁴, Tomas Hajek^{6

15}, Barthomeus C M Haarman¹⁶, Esther Jimenez¹⁷, Beny Lafer¹⁸, Benoit Mulsant¹⁹, Stephen O Oluwaniyi²⁰, Regan Patrick²¹, Joaquim Radua^{17

22

23}, Sigfried Schouws^{4

5}, Harmehr Sekhon^{1

13}, Christian Simhandl²⁴, Jair C Soares^{9

25}, Shang-Ying Tsai²⁶, Eduard Vieta¹⁷, Luca M Villa^{11

27}, Martha Sajatovic²⁸, Lisa T Eyler^{29

30}

Affiliations

¹ Department of Geriatric Psychiatry, Department of Psychiatry, Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Quebec, Canada.
² Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
³ Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, Texas, USA.
⁴ Department of Old Age Psychiatry, GGZ inGeest, Amsterdam, The Netherlands.
⁵ Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam Neuroscience, Amsterdam, The Netherlands.
⁶ Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
⁷ Medical School, University of Western Australia, Perth, Western Australia, Australia.
⁸ Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey.
⁹ Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain.
¹⁰ Laboratório Interdisciplinar de Investigação Médica da Faculdad de Medicina, Universidad Federal de Minas Gerais, Belo Horizonte, Brazil.
¹¹ Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
¹² Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
¹³ Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹⁴ Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, HCFMUSP, Faculdad de Medicina da Universidad de São Paulo, São Paulo, Brazil.
¹⁵ National Institute of Mental Health, Klecany, Czech Republic.
¹⁶ Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
¹⁷ Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
¹⁸ Department of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
¹⁹ Department of Psychiatry, University of Toronto, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
²⁰ Federal Neuro-psychiatric Hospital Yaba, Lagos, Nigeria.
²¹ Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.
²² Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Solna, Sweden.
²³ Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
²⁴ Medical Faculty, Bipolar Center Wiener Neustadt, Sigmund Freud University, Wien, Austria.
²⁵ Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, UTHealth Houston, Texas, USA.
²⁶ Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
²⁷ Department of Psychiatry, University of Oxford, Oxford, UK.
²⁸ Departments of Psychiatry and of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
²⁹ Department of Psychiatry, University of California San Diego, San Diego, California, USA.
³⁰ Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, California, USA.

PMID: 36843436
DOI: 10.1111/bdi.13312

Abstract

Background: By 2030, over 50% of individuals living with bipolar disorder (BD) are expected to be aged ≥50 years. However, older age bipolar disorder (OABD) remains understudied. There are limited large-scale prospectively collected data organized in key dimensions capable of addressing several fundamental questions about BD affecting this subgroup of patients.

Methods: We developed initial recommendations for the essential dimensions for OABD data collection, based on (1) a systematic review of measures used in OABD studies, (2) a Delphi consensus of international OABD experts, (3) experience with harmonizing OABD data in the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD, n ≥ 4500 participants), and (4) critical feedback from 34 global experts in geriatric mental health.

Results: We identified 15 key dimensions and variables within each that are relevant for the investigation of OABD: (1) demographics, (2) core symptoms of depression and (3) mania, (4) cognition screening and subjective cognitive function, (5) elements for BD diagnosis, (6) descriptors of course of illness, (7) treatment, (8) suicidality, (9) current medication, (10) psychiatric comorbidity, (11) psychotic symptoms, (12) general medical comorbidities, (13) functioning, (14) family history, and (15) other. We also recommend particular instruments for capturing some of the dimensions and variables.

Conclusion: The essential data dimensions we present should be of use to guide future international data collection in OABD and clinical practice. In the longer term, we aim to establish a prospective consortium using this core set of dimensions and associated variables to answer research questions relevant to OABD.

Keywords: international collaboration; older age bipolar disorder; prospective studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aging / psychology
Bipolar Disorder* / diagnosis
Bipolar Disorder* / epidemiology
Bipolar Disorder* / therapy
Cognition
Data Collection
Humans
Practice Guidelines as Topic
Prospective Studies

Grants and funding

www.isbd.org/International Society for Bipolar Disorder (ISBD) Bowden Massey Strategic Research Initiative