Objective: To observe the clinical efficacy and safety of Jianpi Peiyuan acupoint thread embedding therapy on perimenopausal obesity (PMO).
Methods: Ninety-six patients of PMO were randomly divided into an observation group (48 cases) and a control group (48 cases). The control group received health education and lifestyle intervention. On the basis of the treatment in the control group, the observation group was treated with acupoint thread embedding at the main acupoints of Shangwan (CV 13), Zhongwan (CV 12), Xiawan (CV 10), Yinlingquan (SP 9) and Fenglong (ST 40), etc. as well as the supplementary acupoints in accordance with the syndrome differentiation, once every 2 weeks for 8 weeks (4 times in total). The indexes of obesity (body mass index [BMI], waist circumference, hip circumference and body mass), modified Kupperman score, insomnia severity index (ISI) score, self-rating anxiety scale (SAS) score, and self-rating depression scale (SDS) score of the two groups were observed before and after treatment, and the safety was evaluated.
Results: After treatment, BMI, waist circumference, hip circumference and body mass in the two groups were lower than before treatment (P<0.05), and those in the observation group were lower than the control group (P<0.05). After treatment, Kupperman, ISI and SAS scores in the observation group were lower than before treatment (P<0.05), and ISI score in the control group was lower than before treatment (P<0.05). Kupperman, ISI and SAS scores in the observation group were lower than those in the control group (P<0.05). There was no significant difference in SDS between the two groups or within groups (P>0.05). No serious adverse reactions occurred during the experiment.
Conclusion: Jianpi Peiyuan acupoint thread embedding therapy can reduce the degree of obesity in PMO patients, and improve patients' the perimenopausal symptoms, insomnia and anxiety, with good safety.
目的：观察“健脾培元”穴位埋线法治疗围绝经期肥胖（PMO）的临床疗效和安全性。方法：将96例PMO患者随机分为观察组（48例）和对照组（48例）。对照组进行健康宣教及生活方式干预；观察组在对照组基础上，加用穴位埋线治疗，以上脘、中脘、下脘、阴陵泉、丰隆等为主穴，并根据辨证配穴，每2周埋线1次，治疗8周（共4次）。于治疗前后观察两组患者肥胖程度指标[体质量指数（BMI）、腰围、臀围、体质量]及改良Kupperman评分、失眠严重程度指数（ISI）评分、焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分，并评定安全性。结果：治疗后，两组患者BMI、腰围、臀围、体质量均较治疗前降低（P<0.05），且观察组低于对照组（P<0.05）。治疗后，观察组Kupperman、ISI、SAS评分均较治疗前降低（P<0.05），对照组ISI评分较治疗前降低（P<0.05）；观察组Kupperman、ISI、SAS评分低于对照组（P<0.05）。两组患者SDS评分组间、组内比较差异均无统计学意义（P>0.05）。试验过程中未发生严重不良反应。结论：“健脾培元”穴位埋线法治疗可以减轻PMO患者肥胖程度，且能改善患者围绝经期症状及失眠、焦虑情况，具有良好的安全性。.
Keywords: acupoint thread embedding; anxiety; insomnia; perimenopausal obesity; randomized controlled trial (RCT).