Keywords: IMLYGIC; T-VEC; acyclovir; adverse events; adverse reactions; dermatology; disseminated herpes infection; drug eruption; drug reactions; drug-induced reactions; herpes encephalitis; herpes simplex virus 1; immunotherapy; intralesional injections; malignant melanoma; melanoma; metastatic melanoma; oncolytic injection; oncolytic virus; regional chemotherapy; regional therapy; skin cancer; surgical oncology; talimogene laherparepvec; valacyclovir; viral dermatitis; viral encephalitis; viral rash.