Soluble amyloid-β dimers are resistant to amyloid-β prion conversion in vivo suggesting antiprion properties

Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12895. doi: 10.1111/nan.12895.

Authors

Else F van Gerresheim¹, Andreas Müller-Schiffmann¹, Sandra Schäble², Bastijn Koopmans³, Maarten Loos³, Carsten Korth¹

Affiliations

¹ Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
² Comparative Psychology, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
³ Sylics (Synaptologics BV), Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands.

PMID: 36861420
DOI: 10.1111/nan.12895

No abstract available

Keywords: Alzheimer's disease; amyloid-beta; antiprion; dimer; plaque formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease*
Amyloid beta-Peptides
Humans
Plaque, Amyloid
Prions*

Substances

Prions
Amyloid beta-Peptides