Early triage of a patient with metastatic melanoma presenting as mechanical knee pain - a case report

J Man Manip Ther. 2023 Aug;31(4):297-303. doi: 10.1080/10669817.2023.2183338. Epub 2023 Mar 3.

Abstract

Physical therapists (PTs) working in primary care settings commonly encounter mechanical causes of knee pain. Non-mechanical causes of knee pain, such as bone tumors, are rare, and therefore, PTs often have a low index of suspicion regarding sinister pathology. The purpose of this case report is to describe the physical therapist's clinical reasoning process for a 33-year-old female presenting with medial knee pain and a subsequent history of metastatic melanoma. Initially, subjective and objective testing pointed to a mechanical internal derangement of the knee. However, symptom progression and poor treatment responses between physical therapy visits 2 and 3 raised suspicions as to the cause of the knee pain. This prompted an orthopedic referral and medical imaging, revealing a large bone tumor invading the medial femoral condyle, which was further characterized as metastatic melanoma by a specialty oncology team. Further imaging revealed several metastatic subcutaneous, intramuscular and cerebral lesions. This case highlights the importance of the ongoing medical screening process, including the monitoring of symptoms and treatment responses.

Keywords: Mechanical knee pain; case report; medical screening; metastatic melanoma; physical therapy; treatment response.

Plain language summary

Clinicians should have a high index of suspicion in patients with a prior cancer diagnosis and unresolving pain without a relevant explanation or injury.The screening process should include active monitoring of treatment responses and appropriate referral for plain radiographs where hypothesized timeframes are exceeded or sinister pathology is suspected.Early specialist referral and subsequent oncology team referral is imperative for bone tumors, to assess metastatic disease and initiate treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms* / diagnosis
  • Bone Neoplasms* / therapy
  • Female
  • Humans
  • Knee
  • Knee Joint* / pathology
  • Melanoma* / therapy
  • Neoplasms, Second Primary*
  • Pain
  • Physical Therapy Modalities
  • Triage

Grants and funding

The author(s) reported there is no funding associated with the work featured in this article.