Review the progression of ovarian clear cell carcinoma from the perspective of genomics and epigenomics

Front Genet. 2023 Feb 16:14:952379. doi: 10.3389/fgene.2023.952379. eCollection 2023.

Abstract

Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer with unique molecular characteristics, specific biological and clinical behavior, poor prognosis and high resistance to chemotherapy. Pushed by the development of genome-wide technologies, our knowledge about the molecular features of OCCC has been considerably advanced. Numerous studies are emerging as groundbreaking, and many of them are promising treatment strategies. In this article, we reviewed studies about the genomics and epigenetics of OCCC, including gene mutation, copy number variations, DNA methylation and histone modifications.

Keywords: epigenomics; genomics; gynecological oncology; ovarian clear cell carcinoma; review.

Publication types

  • Review

Grants and funding

This research was funded by the Natural Science Foundation of Si Chuan Province, grant number No. 2022NSFSC1531; the National Natural Science Foundation of China, grant number No. 81821002; Sichuan Science and Technology Program, grant number 2021YJ0011; Foundation of Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, grant number No. 2022003; Foundation of Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, grant number No. 2023004. The APC was funded by West China Second University Hospital.