The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the "hyperferritinemic syndromes"

Onorina Berardicurti; Luca Navarini; Marta Vomero; Damiano Currado; Alice Biaggi; Annalisa Marino; Pietro Bearzi; Erika Corberi; Amelia Rigon; Luisa Arcarese; Marta Vadacca; Alessia Mattei; Felice Eugenio Agrò; Raffaele Antonelli Incalzi; Federica Sambuco; Francesco Travaglino; Piero Ruscitti; Paola Cipriani; Roberto Giacomelli

doi:10.1016/j.autrev.2023.103309

The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the "hyperferritinemic syndromes"

Autoimmun Rev. 2023 May;22(5):103309. doi: 10.1016/j.autrev.2023.103309. Epub 2023 Mar 6.

Authors

Onorina Berardicurti¹, Luca Navarini², Marta Vomero³, Damiano Currado², Alice Biaggi³, Annalisa Marino³, Pietro Bearzi³, Erika Corberi³, Amelia Rigon⁴, Luisa Arcarese⁴, Marta Vadacca⁴, Alessia Mattei⁵, Felice Eugenio Agrò⁶, Raffaele Antonelli Incalzi⁷, Federica Sambuco⁸, Francesco Travaglino⁸, Piero Ruscitti⁹, Paola Cipriani⁹, Roberto Giacomelli²

Affiliations

¹ Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy; Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy. Electronic address: [email protected].
² Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy; Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.
³ Rheumatology and Clinical Immunology, Department of Medicine, University of Rome "Campus Biomedico", School of Medicine, Rome, Italy.
⁴ Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy.
⁵ Operative Research Unit of Anaesthesia, Intensive Care and Pain Management, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy.
⁶ Operative Research Unit of Anaesthesia, Intensive Care and Pain Management, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy; Anesthesia, Intensive Care and Pain Management, Department of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
⁷ Unit of Geriatrics, Campus Bio-Medico University of Rome, Rome, Italy; Internal Medicine, Fondazione Policiclinico Campus Biomedico, Via Alvaro del Portillo 200, 00128, Rome, Italy.
⁸ Emergency Department, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy.
⁹ Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Abstract

A role for COVID19 in "hyperferritinemic syndromes" has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation.

Keywords: AOSD; COVID19; Hyper-inflammatory syndromes; Hyperferritinemic syndromes; Macrophage activation.

Publication types

Letter

MeSH terms

COVID-19* / complications
COVID-19* / genetics
Ferritins
Humans
Macrophages
Receptors, Scavenger
Still's Disease, Adult-Onset*

Substances

Ferritins
Receptors, Scavenger