Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients: a validation study

Esther Wittermans; Philip A van der Zee; Hongchao Qi; Jan C Grutters; G Paul Voorn; Willem Jan W Bos; Ewoudt M W van de Garde; Henrik Endeman

doi:10.1183/23120541.00577-2022

Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients: a validation study

ERJ Open Res. 2023 Mar 6;9(2):00577-2022. doi: 10.1183/23120541.00577-2022. eCollection 2023 Mar.

Authors

Esther Wittermans^{1

2

3}, Philip A van der Zee^{4

3}, Hongchao Qi⁵, Jan C Grutters^{6

7}, G Paul Voorn⁸, Willem Jan W Bos^{1

2}, Ewoudt M W van de Garde^{9

10}, Henrik Endeman⁴

Affiliations

¹ Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands.
² Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
³ These authors contributed equally.
⁴ Department of Adult Intensive Care, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁵ Department of Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁶ Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.
⁷ Division of Heart and Lungs, Utrecht University Medical Centre, Utrecht, The Netherlands.
⁸ Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands.
⁹ Department of Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
¹⁰ Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Abstract

In patients with community-acquired pneumonia, LCA can identify robust prognostic subgroups based on clinical and inflammatory parameters. Yet, these subgroups have not proven robust in predicting response to adjunctive dexamethasone treatment. https://bit.ly/3O5eaxz.