The oncogenetic landscape and clinical impact of BCL11B alterations in adult and pediatric T-cell acute lymphoblastic leukemia

Marie Emilie Dourthe; Guillaume P Andrieu; Amandine Potier; Estelle Balducci; Julie Guerder; Mathieu Simonin; Lucien Courtois; Arnaud Petit; Elizabeth Macintyre; Nicolas Boissel; André Baruchel; Vahid Asnafi

doi:10.3324/haematol.2022.282605

The oncogenetic landscape and clinical impact of BCL11B alterations in adult and pediatric T-cell acute lymphoblastic leukemia

Haematologica. 2023 Nov 1;108(11):3165-3169. doi: 10.3324/haematol.2022.282605.

Affiliations

¹ Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France; Université de Paris Cité, Department of Pediatric Hematology and Immunology, Robert Debré University Hospital (AP-HP), Paris.
² Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris.
³ Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France; Department of Pediatric Hematology and Oncology, Assistance Publique-Hôpitaux de Paris (AP-HP), GH HUEP, Armand Trousseau Hospital, Paris, France and Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CDR Saint-Antoine, GRC n°07, GRC MyPAC, Paris.
⁴ Department of Pediatric Hematology and Oncology, Assistance Publique-Hôpitaux de Paris (AP-HP), GH HUEP, Armand Trousseau Hospital, Paris, France and Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CDR Saint-Antoine, GRC n°07, GRC MyPAC, Paris.
⁵ AP-HP, Hôpital Saint Louis, Unité d'Hématologie Adolescents et Jeunes Adultes, Paris, France; Université de Paris, Institut de Recherche Saint-Louis, EA-3518, Paris.
⁶ Université de Paris Cité, Department of Pediatric Hematology and Immunology, Robert Debré University Hospital (AP-HP), Paris, France; Université de Paris, Institut de Recherche Saint-Louis, EA-3518, Paris.
⁷ Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris. [email protected].

No abstract available

Publication types

Letter

MeSH terms

Adult
Child
Humans
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Repressor Proteins
T-Lymphocytes
Transcription Factors
Tumor Suppressor Proteins

Substances

Transcription Factors
Tumor Suppressor Proteins
BCL11B protein, human
Repressor Proteins

Grants and funding

Funding: The GRAALL was supported by grants P0200701 and P030425/AOM03081 from the Programme Hospitalier de Recherche Clinique, Ministère de l’Emploi et de la Solidarité, France and the Swiss Federal Government in Switzerland. Samples were collected and processed by the AP-HP “Direction de Recherche Clinique” Tumor Bank at Necker-Enfants Malades. MED was supported by “CARPEM”. MS was supported by « Action Leucémie » and « Soutien pour la formation à la recherche translationnelle en cancérologie dans le cadre du Plan cancer 2009-2013 ». LC was supported by “Fondation pour la Recherche Médicale”. GA was supported by “Fondation de France”. This work was supported by grants to Necker laboratory from the “Association Laurette Fugain”, Institut National du Cancer PRT-K 18-071 and PLBIO2021-097-PL