Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening

Po-Sung Chen; Ju Lee; Hui-Ping Pan; Yuh-Jyh Lin; Yung-Chieh Lin; Yu-Shan Chang; Yen-Ju Chen; Chia-Liang Yen; Ching-Wei Lin; Chih-An Chen; Chi-Chang Shieh

doi:10.1016/j.jmii.2023.02.001

Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening

J Microbiol Immunol Infect. 2023 Aug;56(4):871-874. doi: 10.1016/j.jmii.2023.02.001. Epub 2023 Feb 28.

Authors

Po-Sung Chen¹, Ju Lee², Hui-Ping Pan³, Yuh-Jyh Lin⁴, Yung-Chieh Lin⁴, Yu-Shan Chang⁴, Yen-Ju Chen⁴, Chia-Liang Yen⁵, Ching-Wei Lin⁴, Chih-An Chen⁶, Chi-Chang Shieh⁷

Affiliations

¹ Department of Pediatrics, Sin-Lau Christian Hospital, Tainan, Taiwan; Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan.
² Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan; Department of Pediatrics, Kuo General Hospital, Taiwan.
³ Genetic Center, National Cheng-Kung University Hospital, Tainan, Taiwan.
⁴ Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan.
⁵ Institute of Clinical Medicine, College of Medicine, National Cheng-Kung University Tainan, Taiwan.
⁶ Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan. Electronic address: [email protected].
⁷ Institute of Clinical Medicine, College of Medicine, National Cheng-Kung University Tainan, Taiwan; Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan.

PMID: 36894477
DOI: 10.1016/j.jmii.2023.02.001

Abstract

From 2011, 37 children were referred to a hospital due to low levels of T cell receptor excision circles (TRECs) from newborn screening. Among them, three children were immunologically characterized and followed up to show that postnatal corticosteroid usage may be among the causes of false positivity in TRECs screening.

Keywords: Corticosteroid; False positive; Newborn screening; SCID; Severe combined immunodeficiency.

MeSH terms

Child
DNA
Humans
Infant, Newborn
Neonatal Screening*
Receptors, Antigen, T-Cell
Risk Factors
Severe Combined Immunodeficiency* / diagnosis

Substances

DNA
Receptors, Antigen, T-Cell