Abstract
Activation of protein kinase C by phorbol esters caused a time- and dose-dependent stimulation (270% of control) of glucose uptake in cultured glia, but not in neurons from rat brain. The phorbol ester stimulation of Vmax of glial glucose uptake occurred only in glia despite nearly 2.5-fold greater phorbol ester binding in neurons. These differences in cellular responses to protein kinase C activation may be the key to understanding brain glucose regulation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / cytology*
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Brain / drug effects
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Brain / metabolism
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Cells, Cultured
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Deoxy Sugars / pharmacokinetics*
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Deoxyglucose / pharmacokinetics*
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Neuroglia / drug effects
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Neuroglia / metabolism*
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Neurons / drug effects
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Neurons / metabolism*
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Phorbol Esters / analogs & derivatives
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Phorbol Esters / pharmacology*
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Protein Kinase C / metabolism
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Rats
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Deoxy Sugars
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Phorbol Esters
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Deoxyglucose
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Protein Kinase C
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Tetradecanoylphorbol Acetate