Sputum periostin is a biomarker of type 2 inflammation but not airway dysfunction in asthma

Respirology. 2023 May;28(5):491-494. doi: 10.1111/resp.14491. Epub 2023 Mar 13.

Taha Al-Shaikhly^{1

2}, Ryan C Murphy^{2

3}, Ying Lai^{2

3}, Charles W Frevert^{2

4}, Jason S Debley^{5

6}, Steven F Ziegler⁷, Kit Wong⁸, Guiquan Jia⁸, Cecile T J Holweg⁸, Michael C Peters⁹, Teal S Hallstrand^{2

3}

¹ Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
² Center for Lung Biology, University of Washington, Seattle, Washington, USA.
³ Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington, USA.
⁴ Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
⁵ Department of Pediatrics, Division of Pulmonary and Sleep Medicine, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
⁶ Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
⁷ Immunology Program, Benaroya Research Institute, Seattle, Washington, USA.
⁸ Genentech, South San Francisco, California, USA.
⁹ Department of Medicine, Division of Pulmonary and Critical Care, University of California San Francisco, San Francisco, California, USA.

No abstract available

Keywords: IL-13; IL-4; IL-5; airway hyperresponsiveness; asthma; periostin; type-2.

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