Balance between endothelium-mediated dilating and direct constricting actions of serotonin on resistance vessels in the isolated rabbit heart

D J Stewart; J Holtz; U Pohl; E Bassenge

doi:10.1016/0014-2999(87)90743-6

Balance between endothelium-mediated dilating and direct constricting actions of serotonin on resistance vessels in the isolated rabbit heart

Eur J Pharmacol. 1987 Nov 3;143(1):131-4. doi: 10.1016/0014-2999(87)90743-6.

Authors

D J Stewart¹, J Holtz, U Pohl, E Bassenge

Affiliation

¹ Institute of Applied Physiology, University of Freiburg, F.R.G.

PMID: 3691647
DOI: 10.1016/0014-2999(87)90743-6

Abstract

To determine whether endothelium-derived relaxing factor (EDRF) contributes to the vasomotor action of serotonin (5-HT) in the coronary resistance bed, we used haemoglobin as an inhibitor of EDRF in isolated perfused rabbit hearts. The 5-HT-induced dilatation (14 +/- 2% change in vascular resistance) was converted to constriction (10 +/- 3% change) in the presence of haemoglobin, while the vasodilator responses to papaverine were not attenuated. This is consistent with a role for EDRF in the mediation of 5-HT-induced coronary resistance vessel dilatation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Pressure / drug effects
Coronary Vessels / drug effects*
Endothelium, Vascular / physiology
Heart Rate / drug effects
Hemoglobins / physiology
In Vitro Techniques
Indomethacin / analogs & derivatives
Indomethacin / pharmacology
Rabbits
Serotonin / physiology*
Vascular Resistance / drug effects

Substances

Hemoglobins
Serotonin
Indomethacin