The significance of N6-methyladenosine-modified non-coding RNAs in different disorders

Soudeh Ghafouri-Fard; Hamed Shoorei; Bashdar Mahmud Hussen; Peixin Dong; Tianyue Zhai; Mohammad Taheri; Mohammad Samadian

doi:10.1016/j.ejphar.2023.175644

The significance of N6-methyladenosine-modified non-coding RNAs in different disorders

Eur J Pharmacol. 2023 May 5:946:175644. doi: 10.1016/j.ejphar.2023.175644. Epub 2023 Mar 14.

Authors

Soudeh Ghafouri-Fard¹, Hamed Shoorei², Bashdar Mahmud Hussen³, Peixin Dong⁴, Tianyue Zhai⁴, Mohammad Taheri⁵, Mohammad Samadian⁶

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
⁴ Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.
⁵ Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].
⁶ Department of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

PMID: 36921707
DOI: 10.1016/j.ejphar.2023.175644

Abstract

N6-methyladenosine (m6A) is the most widespread endogenous modification affecting the expression of eukaryotic mRNA transcripts. Recent studies have shown that the m6A marks within non-coding RNAs can affect their functions and expression in a manner similar to that of mRNA-coding genes. Since non-coding RNAs are involved in the pathophysiology of several disorders, identification of the role of m6A marks in the regulation of expression of non-coding RNAs can open a new era for identifying underlying mechanisms of several disorders and designing novel therapeutic modalities for a variety of disorders, particularly cancers. Moreover, a number of non-coding RNAs can affect m6A levels. In the current review, we discuss the impacts of m6A marks on the expression of non-coding RNAs in the context of different disorders, such as bone, gastrointestinal, neurologic, renal, pulmonary, hepatic and other disorders.

Keywords: N6-methyladenosine; Tumor; circRNA; lncRNA; m6A; miRNA.

Publication types

Review

MeSH terms

Adenosine* / genetics
Kidney*
RNA, Messenger

Substances

Adenosine
RNA, Messenger