Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults

Román Romero-Ortuño; Nicolás Martínez-Velilla; Richard Sutton; Andrea Ungar; Artur Fedorowski; Rose Galvin; Olga Theou; Andrew Davies; Richard B Reilly; Jurgen Claassen; Áine M Kelly; Plamen Ch Ivanov

doi:10.3389/fnetp.2021.712430

Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults

Front Netw Physiol. 2021 Jul 7:1:712430. doi: 10.3389/fnetp.2021.712430. eCollection 2021.

Authors

Román Romero-Ortuño^{1

2

3}, Nicolás Martínez-Velilla⁴, Richard Sutton⁵, Andrea Ungar⁶, Artur Fedorowski⁷, Rose Galvin⁸, Olga Theou⁹, Andrew Davies¹⁰, Richard B Reilly^{1

11}, Jurgen Claassen¹², Áine M Kelly¹³, Plamen Ch Ivanov¹⁴

Affiliations

¹ Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
² Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.
³ Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁴ Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Public University of Navarra (UPNA), Navarra Health Research Institute (IdisNa), Pamplona, Spain.
⁵ Faculty of Medicine, Imperial College London, Heart Science, National Heart and Lung Institute, London, United Kingdom.
⁶ Geriatric Department, University of Florence and Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
⁷ Department of Clinical Sciences, Lund University and Department of Cardiology, Skåne University Hospital, Malmo, Sweden.
⁸ Ageing Research Centre, School of Allied Health, Health Research Institute, University of Limerick, Limerick, Ireland.
⁹ Physiotherapy and Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.
¹⁰ School of Medicine, Trinity College Dublin, University College Dublin and Our Lady's Hospice and Care Services, Dublin, Ireland.
¹¹ Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland.
¹² Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
¹³ Discipline of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
¹⁴ Keck Laboratory for Network Physiology, Boston University, Boston, MA, United States.

No abstract available

Keywords: aging frailty; dynamic coupling; network physiology; reserve; resilience.

Publication types

Editorial

Grants and funding

RR-O is funded by Grants from Science Foundation Ireland under Grant numbers 18/FRL/6188 and 20/COV/8493. RG is funded by a Grant from the Health Research Board of Ireland under Grant number RL-2020-010. NM-V received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006. JC is funded by EFRO (Prohealth), NWO (MOCIA), and ZonMW/Health Holland (ABOARD). RR is funded by a Grant from the Health Research Board of Ireland under Grant number ILP-HSR-2017-021. ÁK is funded by a Grand from Science Foundation Ireland under Grant number 19/FFP/6867. PChI is funded by the W.M. Keck Foundation (http://www.wmkeck.org).