Complexity and diversity of FOXP3 isoforms: Novel insights into the regulation of the immune response in metastatic breast cancer

Int Immunopharmacol. 2023 May:118:110015. doi: 10.1016/j.intimp.2023.110015. Epub 2023 Mar 16.

Abstract

FOXP3 is a key transcription factor in the regulation of immune responses, and recent studies have uncovered the complexity and diversity of FOXP3 isoforms in various cancers, including metastatic breast cancers (mBCs). It has dual role in the tumor microenvironment of mBCs. This review aims to provide novel insights into the complexity and diversity of FOXP3 isoforms in the regulation of the immune response in breast cancer. We discuss the molecular mechanisms underlying the function of FOXP3 isoforms, including their interaction with other proteins, regulation of gene expression, and impact on the immune system. We also highlight the importance of understanding the role of FOXP3 isoforms in breast cancer and the potential for using them as therapeutic targets. This review highlights the crucial role of FOXP3 isoforms in the regulation of the immune response in breast cancer and underscores the need for further research to fully comprehend their complex and diverse functions.

Keywords: Breast cancer; FOXP3; Prognosis; Tregs; Tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms*
  • Female
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Immunity
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • T-Lymphocytes, Regulatory
  • Tumor Microenvironment

Substances

  • Protein Isoforms
  • Forkhead Transcription Factors
  • FOXP3 protein, human