Liver-stage Plasmodium infection tunes clinical outcomes

Trends Parasitol. 2023 May;39(5):321-322. doi: 10.1016/j.pt.2023.03.004. Epub 2023 Mar 17.

Abstract

Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (ɣδ) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.

Keywords: IL-17; erythropoiesis; experimental cerebral malaria; liver-stage Plasmodium immunity; natural immunity to malaria; ɣδ T cell.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Communicable Diseases*
  • Humans
  • Liver Diseases*
  • Malaria, Cerebral*
  • Plasmodium berghei