HOW TO OPTIMALLY SEQUENCE AVAILABLE THERAPY LINES IN ADVANCED PROSTATE CANCER

Acta Clin Croat. 2022 Oct;61(Suppl 3):32-44. doi: 10.20471/acc.2022.61.s3.5.

Abstract

Optimal sequencing of available therapy lines in patients with advanced prostate cancer often poses quite a challenge. The guidelines are sometimes equivocal and clinical trial data are not always applicable to a particular patient. There is a difference in availability of therapy options throughout the world. In decision making, a patient as a whole should be taken into consideration, not just the stage and biology of the disease, but also patient's age, performance status, comorbidities, previous therapy lines, drug's safety profile and patient's preferences. This review article will show certain therapeutic options in the treatment of advanced hormone-sensitive prostate cancer and castration resistant prostate cancer: non- metastatic and metastatic. An attempt will be made to clarify the optimal sequencing.

Keywords: Advanced prostate cancer; Radium 223; abiraterone; androgen deprivation therapy; apalutamide; cabazitaxel; castration resistant prostate cancer; darolutamide; docetaxel; enzalutamide; hormone sensitive prostate cancer.

Publication types

  • Review

MeSH terms

  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant* / chemically induced
  • Prostatic Neoplasms, Castration-Resistant* / drug therapy
  • Taxoids / adverse effects

Substances

  • Taxoids