Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii

Yoshihiko Maehara; Eiji Oki; Mitsuhiko Ota; Norifumi Harimoto; Koji Ando; Ryota Nakanishi; Tetsuro Kawazoe; Yoshiaki Fujimoto; Kentaro Nonaka; Hiroyuki Kitao; Makoto Iimori; Kunio Makino; Teiji Takechi; Takeshi Sagara; Kazutaka Miyadera; Kazuaki Matsuoka; Hiroshi Tsukihara; Yuki Kataoka; Takeshi Wakasa; Hiroaki Ochiiwa; Yoshihiro Kamahori; Eriko Tokunaga; Hiroshi Saeki; Tomoharu Yoshizumi; Yoshihiro Kakeji; Ken Shirabe; Hideo Baba; Mitsuo Shimada

doi:10.1007/s10147-023-02326-w

Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii

Int J Clin Oncol. 2023 May;28(5):613-624. doi: 10.1007/s10147-023-02326-w. Epub 2023 Mar 24.

Authors

Yoshihiko Maehara¹, Eiji Oki², Mitsuhiko Ota², Norifumi Harimoto³, Koji Ando², Ryota Nakanishi², Tetsuro Kawazoe², Yoshiaki Fujimoto², Kentaro Nonaka², Hiroyuki Kitao^{4

5}, Makoto Iimori^{4

5}, Kunio Makino⁶, Teiji Takechi⁷, Takeshi Sagara⁷, Kazutaka Miyadera⁷, Kazuaki Matsuoka⁷, Hiroshi Tsukihara⁷, Yuki Kataoka⁷, Takeshi Wakasa⁷, Hiroaki Ochiiwa⁷, Yoshihiro Kamahori⁶, Eriko Tokunaga⁸, Hiroshi Saeki³, Tomoharu Yoshizumi², Yoshihiro Kakeji⁹, Ken Shirabe³, Hideo Baba¹⁰, Mitsuo Shimada¹¹

Affiliations

¹ Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, 815-8588, Japan. [email protected].
² Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
³ Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, 371-8511, Japan.
⁴ Oral Medicine Research Center, Fukuoka Dental College, Fukuoka, 814-0193, Japan.
⁵ Department of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
⁶ Division of Clinical Development and Medical Affairs, Taiho Pharmaceutical Co. Ltd, Tokyo, 101-8444, Japan.
⁷ Discovery and Preclinical Research Division, Taiho Pharmaceutical Co. Ltd, Tsukuba, 300-2611, Japan.
⁸ Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, 811-1347, Japan.
⁹ Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
¹⁰ Department of Gastroenterological Surgery, Kumamoto University, 1-1-1, Honjyo, Chuo-Ku, Kumamoto, 860-8556, Japan.
¹¹ Department of Surgery, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.

PMID: 36961615
DOI: 10.1007/s10147-023-02326-w

Abstract

Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are therapeutic drugs for various other diseases. He delivered hope to patients with various diseases across the world to improve their condition. Even now, drug discovery research based on Dr. Fujii's ideas is continuing.

Keywords: 5-Fluorouracil; Camostat mesilate; Cancer chemotherapy; Cetraxate hydrochloride; Gabexate mesilate; Nafamostat mesilate; Pravastatin sodium; Senescence; Tegafur; Tegafur and uracil; Tegafur, gimeracil and oteracil; Trifluridine and tipiracil hydrochloride.

MeSH terms

Antineoplastic Agents* / therapeutic use
Gabexate* / therapeutic use
Humans
Japan
Male
Pyrimidines
Tegafur / therapeutic use
Uracil

Substances

Pyrimidines
Gabexate
Antineoplastic Agents
Tegafur
Uracil