Study on naked eye tracing of inguinal sentinel lymph nodes in penile cancer patients with carbon nanoparticle suspension injection

Chengyi Liu; Pengcheng Xu; Song Shao; Mingshan Yang; Chao Li; Shuangjie Li; Wei Liu; Xiaobo Ding; Jici Ma; Guangyuan Li

doi:10.3389/fmed.2023.1139986

Study on naked eye tracing of inguinal sentinel lymph nodes in penile cancer patients with carbon nanoparticle suspension injection

Front Med (Lausanne). 2023 Mar 9:10:1139986. doi: 10.3389/fmed.2023.1139986. eCollection 2023.

Authors

Chengyi Liu¹, Pengcheng Xu¹, Song Shao², Mingshan Yang³, Chao Li¹, Shuangjie Li¹, Wei Liu¹, Xiaobo Ding¹, Jici Ma¹, Guangyuan Li^{1

4}

Affiliations

¹ Department of Urology, LU'AN Affiliated Hospital of Anhui Medical University, Lu'an, Anhui, China.
² Department of Orthopaedic, LU'AN Affiliated Hospital of Anhui Medical University, Lu'an, Anhui, China.
³ Department of Urology, Shandong Cancer Hospital, Affiliated Tumor Hospital of Shandong First Medical University, Ji'nan, Shandong, China.
⁴ The First Affiliated Hospital of Anhui Medical University, Anhui Public Health Clinical Center, Hefei, Anhui, China.

Abstract

Objective: Exploratory study of the effect and clinical value of carbon nanoparticle suspension injection (CNSI) as a tracer for inguinal sentinel lymph nodes in penile cancer.

Method: We selected 29 patients with penile cancer in our department from January 2019 to October 2022. According to whether the CNSI tracer was injected during the pathological biopsy of the inguinal lymph nodes, the enrolled patients were assigned to the control group, the group in which CNSI was injected 12 h before the surgery (12HBS group) and the group in which CNSI was injected 0.5 h before the surgery (0.5HBS group). Evaluating the effectiveness of CNSI as a lymphatic tracer involves analyzing the following: its safety, the statistical analysis of the detection rate (DR) of different groups, the number of lymph nodes sent for each case (NOLNSFEC), the difference of positive rate of lymphatic metastasis (PROLM), and operation time (OT).

Results: The lymph nodes in the 12HBS group and 0.5HBS group had an obvious black staining appearance, and no adverse reactions or surgical complications were found. Most of the black-stained areas caused by CNSI injection were removed with penile excision, which did not affect the postoperative appearance. This did not affect the pathological analysis. The DR of lymph nodes in the 12HBS group was higher (p < 0.05) than that in the control group. More lymph nodes were removed for examination (p < 0.05), which improved the efficiency of surgery. Compared with the 12HBS group, the number of lymph nodes removed in the 0.5HBS group decreased (p < 0.05). The OT was shortened (p < 0.05), but there was no significant difference in the DR and PROLM.

Conclusion: CNSI was applied to the naked-eye tracing of inguinal sentinel lymph nodes in penile cancer, which is safe and efficient. Injection of CNSI 0.5 h before surgery can help identify the "foremost position" of sentinel lymph nodes and reduce surgical trauma.

Keywords: CNSI; naked eye; penile carcinoma; sentinel lymph node; tracer.