Sinus node dysfunction and related permanent pacemaker implantation after major cardiac surgeries, systematic review, and meta-analysis

Reza Hosseini Dolama; Amir Hosein Eghbal; Malihe Rezaee; Ali Vasheghani Farahani; Arash Jalali; Kaveh Hosseini

doi:10.3389/fcvm.2023.1091312

Sinus node dysfunction and related permanent pacemaker implantation after major cardiac surgeries, systematic review, and meta-analysis

Front Cardiovasc Med. 2023 Mar 10:10:1091312. doi: 10.3389/fcvm.2023.1091312. eCollection 2023.

Authors

Reza Hosseini Dolama^{1

2}, Amir Hosein Eghbal¹, Malihe Rezaee^{2

3}, Ali Vasheghani Farahani^{2

4}, Arash Jalali², Kaveh Hosseini^{2

4}

Affiliations

¹ Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
² Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: There is no concise evidence or clinical guidelines regarding the incidence of sinus node dysfunction (SND) and permanent pacemaker (PPM) implantation following cardiac surgeries and their management approaches.

Objective: We aim to systematically review current evidence on the prevalence of SND, PPM implantation concerning it, and its risk factors in patients undergoing cardiac surgery.

Method: Four electronic databases (Cochrane Library, Medline, SCOPUS, and Web of Science) were systematically searched for articles regarding SND after cardiovascular surgeries and reviewed by two independent researchers, and a third review in case of discrepancies. Using the random-effects model, a proportion meta-analysis was performed on data regarding PPM implantation. Subgroup analysis was performed for different interventions, and the possible effect of different covariates was evaluated using meta-regression.

Results: From the initial 2012 unique records, 87 were included in the study, and results were extracted. Pooled data from 38,519 patients indicated that the overall prevalence of PPM implantation due to SND after cardiac surgery was 2.87% (95% CI [2.09; 3.76]). The incidence of PPM implantation in the first post-surgical month was 2.707% (95% CI [1.657; 3.952]). Among the four main intervention groups, including valve, maze, valve-maze, and combined surgeries, maze surgery was associated with the highest prevalence (4.93%; CI [3.24; 6.92]). The pooled prevalence of SND among studies was 13.71% (95% CI [8.13; 20.33]). No significant relationship was observed between PPM implantation and age, gender, cardiopulmonary bypass time, or aortic cross-clamp time.

Conclusion: Based on the present report, patients undergoing the maze and maze-valve procedures are at higher risk of post-op SND, whereas lone valve surgery had the lowest prevalence of PPM implantation.

Systematic review registration: PROSPERO (CRD42022341896).

Keywords: cardiac surgery; cox-maze procedure; permanent pacemaker; sinus node dysfunction; valve surgery.

Publication types

Review