Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

Cancer Res. 2023 Jun 2;83(11):1768-1781. doi: 10.1158/0008-5472.CAN-22-3030.

Abstract

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Cell Transformation, Neoplastic
  • Cervix Uteri
  • Female
  • Human Papillomavirus Viruses
  • Humans
  • Papillomaviridae / genetics
  • Papillomavirus Infections* / complications
  • Plasmids
  • Uterine Cervical Neoplasms* / genetics