Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells

Cancer Res. 2023 Jun 2;83(11):1815-1833. doi: 10.1158/0008-5472.CAN-22-3864.

Abstract

Cross-talk with TTEX CD8+ T cells mediated by the VEGFR2 axis induces aggressive properties in cancer stem cells to promote tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD8-Positive T-Lymphocytes
  • Humans
  • Neoplasms*
  • Neoplastic Stem Cells
  • Programmed Cell Death 1 Receptor*

Substances

  • Programmed Cell Death 1 Receptor