Pathophysiological Roles of the cGAS-STING Inflammatory Pathway

Hiroshi Maekawa; Margaret Elizabeth Fain; Koichiro Wasano

doi:10.1152/physiol.00031.2022

Pathophysiological Roles of the cGAS-STING Inflammatory Pathway

Physiology (Bethesda). 2023 Jul 1;38(4):0. doi: 10.1152/physiol.00031.2022. Epub 2023 Mar 28.

Authors

Hiroshi Maekawa^{1

2}, Margaret Elizabeth Fain^{1

2}, Koichiro Wasano³

Affiliations

¹ Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
² Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.

PMID: 36976098
DOI: 10.1152/physiol.00031.2022

Abstract

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) inflammatory pathway is a component of the innate immune system that recognizes cytosolic nucleic acids. The pathway has been implicated in several processes including aging, autoinflammatory conditions, cancer, and metabolic diseases. The cGAS-STING pathway represents a promising therapeutic target in a variety of chronic inflammatory diseases.

Keywords: cGAS-STING pathway; cancer; inflammatory diseases; senescence.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunity, Innate
Neoplasms*
Nucleotidyltransferases / genetics
Nucleotidyltransferases / metabolism
Signal Transduction*

Substances

Nucleotidyltransferases