Practical evaluation of a warm-reactive anti-M

X Yang; J M Syrjamaki; P A Ruegsegger; C T Rohrer; W N Rose

doi:10.21307/immunohematology-2023-004

Practical evaluation of a warm-reactive anti-M

Immunohematology. 2023 Apr 5;39(1):15-18. doi: 10.21307/immunohematology-2023-004. Print 2023 Apr 1.

Authors

X Yang¹, J M Syrjamaki², P A Ruegsegger³, C T Rohrer⁴, W N Rose⁵

Affiliations

¹ MD, PhD, Resident Physician, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, US.
² MLS(ASCP)CM, SBBCM, Senior Medical Technologist, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, US.
³ MT(ASCP), SBBCM, Senior Medical Technologist, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, US.
⁴ MD, Resident Physician, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, US.
⁵ MD, Associate Professor, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, US.

PMID: 37017598
DOI: 10.21307/immunohematology-2023-004

Abstract

Anti-M is usually a naturally occurring antibody directed against M in the MNS blood group system. It does not require exposure to the antigen from previous transfusion or pregnancy. Anti-M is usually of the immunoglobulin M (IgM) isotype, binds best at about 4°C, binds well at room temperature, and rarely binds at 37°C. As a result of its lack of binding at 37°C, anti-M is usually clinically insignificant. There have been rare cases reported of an anti-M that reacts at 37°C. Such an exceptional anti-M may cause hemolytic transfusion reactions. We report a case of a warm-reactive anti-M and the investigational process used to identify it.

Keywords: MNS blood group system; immunohematology; warm-reactive anti-M.

Publication types

Case Reports

MeSH terms

Blood Transfusion*
Female
Humans
Immunoglobulin M
Pregnancy
Transfusion Reaction*

Substances

Immunoglobulin M