Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration

Liping Tong; Di Chen

doi:10.1016/j.cmet.2023.03.009

Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration

Cell Metab. 2023 Apr 4;35(4):551-553. doi: 10.1016/j.cmet.2023.03.009.

Authors

Liping Tong¹, Di Chen²

Affiliations

¹ Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address: [email protected].
² Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Shenzhen 518055, China. Electronic address: [email protected].

PMID: 37019078
DOI: 10.1016/j.cmet.2023.03.009

Abstract

Glucocorticoid (GC)-induced osteoporosis is the most common secondary cause of osteoporosis, resulting in fractures and significant morbidity. In this issue of Cell Metabolism, Liu et al. reveal that in response to GCs, bone marrow adipocytes (BMAds) undergo rapid cellular senescence, triggering secondary senescence in bone marrow and causing bone deterioration.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipocytes / metabolism
Bone Marrow / metabolism
Bone Marrow Cells / metabolism
Bone and Bones / metabolism
Glucocorticoids* / metabolism
Humans
Osteoporosis* / metabolism

Substances

Glucocorticoids