MR Elastography With Optimization-Based Phase Unwrapping and Traveling Wave Expansion-Based Neural Network (TWENN)

IEEE Trans Med Imaging. 2023 Sep;42(9):2631-2642. doi: 10.1109/TMI.2023.3261346. Epub 2023 Aug 31.

Abstract

Magnetic Resonance Elastography (MRE) can characterize biomechanical properties of soft tissue for disease diagnosis and treatment planning. However, complicated wavefields acquired from MRE coupled with noise pose challenges for accurate displacement extraction and modulus estimation. Using optimization-based displacement extraction and Traveling Wave Expansion-based Neural Network (TWENN) modulus estimation, we propose a new pipeline for processing MRE images. An objective function with Dual Data Consistency (Dual-DC) has been used to ensure accurate phase unwrapping and displacement extraction. For the estimation of complex wavenumbers, a complex-valued neural network with displacement covariance as an input has been developed. A model of traveling wave expansion is used to generate training datasets for the network with varying levels of noise. The complex shear modulus map is obtained through fusion of multifrequency and multidirectional data. Validation using brain and liver simulation images demonstrates the practical value of the proposed pipeline, which can estimate the biomechanical properties with minimal root-mean-square errors when compared to state-of-the-art methods. Applications of the proposed method for processing MRE images of phantom, brain, and liver reveal clear anatomical features, robustness to noise, and good generalizability of the pipeline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Elasticity Imaging Techniques* / methods
  • Image Processing, Computer-Assisted / methods
  • Liver / diagnostic imaging
  • Magnetic Resonance Imaging / methods
  • Neural Networks, Computer