Intravesical aminoglycoside instillations as prophylaxis for recurrent urinary tract infection: patient satisfaction, long-term safety and efficacy

Manu P Bilsen; Janneke I M van Uhm; Janneke E Stalenhoef; Cees van Nieuwkoop; Rolf H H Groenwold; Leo G Visser; Merel M C Lambregts

doi:10.1093/jacamr/dlad040

Intravesical aminoglycoside instillations as prophylaxis for recurrent urinary tract infection: patient satisfaction, long-term safety and efficacy

JAC Antimicrob Resist. 2023 Apr 6;5(2):dlad040. doi: 10.1093/jacamr/dlad040. eCollection 2023 Apr.

Authors

Manu P Bilsen¹, Janneke I M van Uhm², Janneke E Stalenhoef³, Cees van Nieuwkoop⁴, Rolf H H Groenwold⁵, Leo G Visser¹, Merel M C Lambregts¹

Affiliations

¹ Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Urology, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Internal Medicine, OLVG, Amsterdam, The Netherlands.
⁴ Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
⁵ Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Background: Recurrent urinary tract infections (UTIs) are common, especially in women. When oral antimicrobial prophylaxis is ineffective or not possible due to allergies or antimicrobial resistance, intravesical aminoglycoside instillations (IAIs) are a non-systemic alternative.

Objectives: To assess treatment satisfaction, long-term safety and efficacy of IAIs for recurrent UTI.

Methods: We conducted a cohort study using data collected between January 2013 and June 2022 at the Leiden University Medical Center. Adult patients with recurrent UTI who received prophylactic IAI were eligible for inclusion. Treatment satisfaction was assessed through a survey. Data on serum aminoglycoside concentrations, cystoscopy results and number of recurrences were obtained through chart review. Number of recurrences and UTI characteristics were compared between patients on and off IAI using Poisson and logistic mixed effects models.

Results: Forty-four patients were included (median follow-up time 976 days) and 323 UTIs occurred during follow-up. Overall treatment satisfaction was high (median 79.2/100). All but one patient had undetectable serum aminoglycoside levels and no malignancies were found on follow-up cystoscopy. IAI increased the time to first recurrence (102 days versus 36 days, P = 0.02), reduced the number of recurrences (rate ratio 0.75, 95% CI 0.56-0.99, P = 0.04) and the necessity for systemic antibiotics (OR 0.33, 95% CI 0.13-0.86, P = 0.02).

Conclusions: In patients with recurrent UTI, IAI was associated with high treatment satisfaction, and was found to be a safe and effective alternative to oral antimicrobial prophylaxis.